Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
ACS Nano. 2013 Jun 25;7(6):5320-9. doi: 10.1021/nn4011686. Epub 2013 May 30.
A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.
一种基于载光敏剂的金纳米粒子（GNPs）等离子体囊泡组装体的多功能治疗学平台被开发用于有效的癌症成像和治疗。由组装的 GNPs 单层组成的金囊泡（GVs）在近红外（NIR）范围 650-800nm 处显示出强吸收，这是由于囊泡膜中相邻 GNPs 之间的等离子体耦合效应。强的 NIR 吸收和封装光敏剂 Ce6 的能力使 GVs 能够实现三模态 NIR 荧光/热/光声成像引导的协同光热/光动力治疗（PTT/PDT），从而提高疗效。载有 Ce6 的 GV（GV-Ce6）具有以下特点：（i）高 Ce6 负载效率（高达约 18.4wt%）；（ii）增强 Ce6 的细胞摄取效率；（iii）同时进行三模态 NIR 荧光/热/光声成像；（iv）协同 PTT/PDT 治疗，使用单波长连续波激光照射，疗效提高。
