Kees U R, Lukeis R, Ford J, Willoughby M L, Garson O M
Leukemia Research Laboratory, Princess Margaret Hospital, Perth, Western Australia.
Cancer Genet Cytogenet. 1990 Jun;46(2):201-8. doi: 10.1016/0165-4608(90)90105-j.
Cell line PER-278 was established from a bone marrow sample of a 10-year-old boy diagnosed with pre-B acute lymphoblastic leukemia (ALL). PER-278 cells show the pre-B phenotype, express cytoplasmic Ig, and exhibit two translocations: t(1;19)(q23;p13) and t(1;9)(q23;p13). Assessment of the immunoglobulin rearrangements confirmed the clonal origin of cell line PER-278, and comparison with the patients's leukemic cells showed an identical pattern: loci involved at the breakpoint on chromosome 1 code for the oncogene SKI and for the Fc receptor II and on chromosome 19 for the insulin receptor. The t(1;19) may contribute to the malignant transformation in leukemic cells of pre-B phenotype.
细胞系PER - 278是从一名被诊断为前B细胞急性淋巴细胞白血病（ALL）的10岁男孩的骨髓样本中建立的。PER - 278细胞表现出前B细胞表型，表达细胞质免疫球蛋白，并呈现两种易位：t(1;19)(q23;p13)和t(1;9)(q23;p13)。免疫球蛋白重排的评估证实了细胞系PER - 278的克隆起源，并且与患者的白血病细胞比较显示出相同的模式：1号染色体断点处涉及的位点编码原癌基因SKI和Fc受体II，而19号染色体上的位点编码胰岛素受体。t(1;19)可能促成前B细胞表型白血病细胞的恶性转化。
