Webber L M, Garson O M, Tate B, McKenzie I F, Hogarth P M
Department of Cytogenetics and Medicine, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
Immunogenetics. 1990;31(5-6):356-60. doi: 10.1007/BF02115010.
We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitting of the FCGR2 gene or gene cluster by the t(1;19). However, Southern analysis showed no genetic rearrangement when compared with a karyotypically normal Epstein-Barr virus (EBV)-transformed cell line from the same patient. This suggests that the translocation breakpoint does not occur within the coding region of this gene.
