Skrha J, Svacina S, Masek Z
III. interní katedra fakulty vseobecného lékarství Univerzity Karlovy, Praha.
Cas Lek Cesk. 1990 Mar 23;129(12):357-60.
The serum fructosamine concentration was evaluated in 22 diabetics on admission to hospital and after intensified treatment with an insulin pump which was indicated on account of decompensation of diabetes. The drop of the mean glucose concentration in blood after 12 days of treatment correlated with the statistically significant drop of the serum fructose concentration (r = 0.69, p less than 0.001). Between the glucose and fructosamine serum concentration no relationship was observed, as long as the mean glucose concentration was calculated for a period shorter than the previous seven days. A highly significant correlation was observed between the rate of fructosamine decline and the mean blood sugar level (r = 0.94, p less than 0.001). From the dynamic changes ensues that when the mean blood sugar level declined by 1 mmol/l, the fructosamine level declined on average by 0.13 mmol/l. The results suggest a more rapid turnover of glycosylated proteins, as compared with data in the literature pertaining to non-glycosylated proteins.
对22名糖尿病患者入院时及因糖尿病失代偿而使用胰岛素泵强化治疗后的血清果糖胺浓度进行了评估。治疗12天后血液中平均葡萄糖浓度的下降与血清果糖浓度的显著下降相关（r = 0.69，p < 0.001）。只要计算的平均葡萄糖浓度时间段短于前七天，就未观察到葡萄糖与血清果糖胺浓度之间的关系。果糖胺下降速率与平均血糖水平之间观察到高度显著的相关性（r = 0.94，p < 0.001）。从动态变化可知，当平均血糖水平下降1 mmol/l时，果糖胺水平平均下降0.13 mmol/l。结果表明，与文献中关于非糖基化蛋白质的数据相比，糖基化蛋白质的周转更快。
