[Cancer risk among shift workers: a review].

INTRODUCTION

According to IARC, shift work resulting in disruption of circadian rhythm is a probable human carcinogen (Group 2A).

METHODS

We examined the scientific literature on the carcinogenic risk among shift workers for risk assessment purposes.

RESULTS

Clock genes polymorphisms might contribute with suppression of melatonin synthesis, immuno-suppression from sleep deprivation, individual habits associated with shift work, and low vitamin D levels, in increasing risk of breast cancer, prostate cancer and lymphoma among shift workers.

CONCLUSION

Although the epidemiological evidence seems scanty, the hypothesis that shift work-related sleep deprivation would contribute to increasing cancer risk seems based on solid ground.