Kambam J, Meszaros R, Merrill W, Stewart J, Smith B E, Bender H
Department of Anaesthesiology, Vanderbilt University School of Medicine, Nashville, Tennessee.
Can J Anaesth. 1990 May;37(4 Pt 1):420-2. doi: 10.1007/BF03005618.
We studied the effects of the prophylactic administration of histamine1 and histamine2 receptor blockers on haemodynamic changes, including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MBP), central venous pressure (CVP), and heart rate (HR, beats.min-1) before and after the administration of protamine in two groups of patients having coronary artery bypass graft surgery. Group I patients received no histamine blockers, whereas patients in Group II were treated prophylactically with both H1 (diphenhydramine) and H2 (cimetidine) receptor blockers. The mean SBP, DBP, MBP, CVP, and HR before (and after) administration of protamine in group I patients were 114 +/- 16 (90 +/- 16) mmHg, 64 +/- 11 (51 +/- 8) mmHg, 81 +/- 11 (65 +/- 10) mmHg, 10 +/- 3 (11 +/- 7) mmHg, and 92 +/- 10 (87 +/- 13) before (and after) protamine administration. Group II patients had mean SBP, DBP, MBP, CVP, and HR of 113 +/- 19 (113 +/- 17) mmHg, 61 +/- 12 (62 +/- 11) mmHg, 79 +/- 15 (80 +/- 13) mmHg, 9 +/- 3 (9 +/- 2) mmHg, and 88 +/- 6 (86 +/- 4) before (and after) protamine administration. Our data show that only in Group I patients who did not receive histamine receptor blockers, were there significant haemodynamic changes following protamine administration (P less than 0.05). We conclude that the prophylactic administration of histamine receptor blockers prevents some of the adverse haemodynamic effects associated with protamine administration.
我们研究了组胺1和组胺2受体阻滞剂预防性给药对两组接受冠状动脉搭桥手术患者在注射鱼精蛋白前后血流动力学变化的影响，这些变化包括收缩压（SBP）、舒张压（DBP）、平均动脉压（MBP）、中心静脉压（CVP）和心率（HR，次/分钟）。第一组患者未接受组胺阻滞剂，而第二组患者预防性接受了H1（苯海拉明）和H2（西咪替丁）受体阻滞剂治疗。第一组患者在注射鱼精蛋白前（及后）的平均SBP、DBP、MBP、CVP和HR分别为114±16（90±16）mmHg、64±11（51±8）mmHg、81±11（65±10）mmHg、10±3（11±7）mmHg和92±10（87±13）次/分钟。第二组患者在注射鱼精蛋白前（及后）的平均SBP、DBP、MBP、CVP和HR分别为113±19（113±17）mmHg、61±12（62±11）mmHg、79±15（80±13）mmHg、9±3（9±2）mmHg和88±6（86±4）次/分钟。我们的数据表明，只有在未接受组胺受体阻滞剂的第一组患者中，注射鱼精蛋白后出现了显著的血流动力学变化（P＜0.05）。我们得出结论，组胺受体阻滞剂的预防性给药可预防一些与鱼精蛋白给药相关的不良血流动力学效应。
