Valen G, Kaszaki J, Nagy S, Vaage J
Department of Surgery, University of Tromsø, Norway.
Agents Actions. 1994 Mar;41(1-2):11-6. doi: 10.1007/BF01986386.
The possible release of histamine into the coronary circulation during reperfusion of the cold, cardioplegic heart was investigated during open heart surgery in 13 patients (cardioplegic arrest 54 (35-120 min) (median (range)), cardiopulmonary bypass (CPB) 96 (65-360) min. Samples were drawn concomitantly from coronary sinus and arterial blood before cardioplegia and during myocardial reperfusion for measurement of histamine (radioenzymatic method). Additional arterial samples were drawn pre-, per- and postoperatively. CPB induced a sustained increase in arterial histamine (from 4.02 +/- 2.71 nmol/l preoperatively (mean +/- SD) to maximum 16.31 +/- 7.12 nmol/l, p < 0.009). Immediately before cardioplegia histamine levels were higher in arterial than coronary sinus blood (9.24 +/- 4.85 versus 4.04 +/- 2.07 nmol/l, p < 0.002). During myocardial reperfusion coronary sinus histamine increased to levels similar to that of arterial blood. In conclusion, histamine is released during CPB. Before cardioplegic arrest, there is a net uptake of histamine by the heart, which is abolished during reperfusion, possibly due to increased cardiac release of histamine.
在13例心脏直视手术患者中，研究了冷停搏心脏再灌注期间组胺可能释放至冠脉循环的情况（停搏时间54（35 - 120分钟）（中位数（范围）），体外循环（CPB）96（65 - 360）分钟）。在心脏停搏前和心肌再灌注期间，同时从冠状窦和动脉血中取样以测定组胺（放射酶法）。术前、术中及术后还采集了额外的动脉血样。CPB导致动脉组胺持续升高（从术前的4.02±2.71 nmol/L（均值±标准差）升至最高16.31±7.12 nmol/L，p < 0.009）。就在心脏停搏前，动脉血中的组胺水平高于冠状窦血（9.24±4.85对4.04±2.07 nmol/L，p < 0.002）。在心肌再灌注期间，冠状窦组胺升高至与动脉血相似的水平。总之，CPB期间组胺会释放。在心脏停搏前，心脏对组胺有净摄取，而再灌注期间这种摄取消失，可能是由于心脏组胺释放增加所致。
