Briana Despina D, Boutsikou Maria, Boutsikou Theodora, Malamitsi-Puchner Ariadne
Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
J Matern Fetal Neonatal Med. 2013 Aug;26(12):1219-22. doi: 10.3109/14767058.2013.775420. Epub 2013 Mar 19.
To investigate possible associations of the novel adipocytokines resistin, apelin and visfatin (implicated in the complex control of bone biology) with several biochemical determinants of bone turnover in maternal blood from normal pregnancies and pregnancies complicated by gestational hypertensive disorders (preeclampsia or pregnancy-induced hypertension).
Circulating maternal concentrations of resistin, apelin and visfatin were correlated with circulating markers of bone formation [osteocalcin (OC), bone-specific alkaline phosphatase (BALP)] and resorption [osteoprotegerin (OPG), soluble receptor activator of nuclear factor-κB ligand (sRANKL) and cross-linked N-telopeptide of type I collagen (NTx)] in full-term pregnancies (20 normal and 20 complicated by gestational hypertensive disorders).
In normal pregnancies, no correlation was recorded between maternal concentrations of adipocytokines and the above bone biomarkers. In pregnancies with gestational hypertensive disorders, maternal apelin concentrations negatively correlated with NTx ones (r = -0.489, p = 0.034), while maternal visfatin concentrations positively correlated with OPG ones (r = 0.464, p = 0.039).
No associations were found between maternal concentrations of all three studied adipocytokines and respective concentrations of bone biomarkers in normal pregnancies. By contrast, in pregnancies with gestational hypertensive disorders, maternal concentrations of apelin and visfatin correlated with respective concentrations of indices of bone turnover. Further prospective studies are needed to clarify these relationships.
研究新型脂肪细胞因子抵抗素、脂联素和内脂素（参与骨骼生物学的复杂调控）与正常妊娠及合并妊娠期高血压疾病（子痫前期或妊娠高血压）孕妇血液中几种骨转换生化指标之间的可能关联。
在足月妊娠（20例正常妊娠和20例合并妊娠期高血压疾病）中，将孕妇血液中抵抗素、脂联素和内脂素的循环浓度与骨形成标志物[骨钙素（OC）、骨特异性碱性磷酸酶（BALP）]和骨吸收标志物[骨保护素（OPG）、核因子κB受体活化因子配体可溶性受体（sRANKL）和I型胶原交联N端肽（NTx）]进行相关性分析。
在正常妊娠中，未发现脂肪细胞因子的母体浓度与上述骨生物标志物之间存在相关性。在合并妊娠期高血压疾病的妊娠中，母体脂联素浓度与NTx浓度呈负相关（r = -0.489，p = 0.034），而母体内脂素浓度与OPG浓度呈正相关（r = 0.464，p = 0.039）。
在正常妊娠中未发现所研究的三种脂肪细胞因子的母体浓度与骨生物标志物的相应浓度之间存在关联。相比之下，在合并妊娠期高血压疾病的妊娠中，母体脂联素和内脂素浓度与骨转换指标的相应浓度相关。需要进一步的前瞻性研究来阐明这些关系。
