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短DNA螺旋的弯曲

Bending of short DNA helices.

作者信息

Vologodskii Alexander, Du Quan, Frank-Kamenetskii Maxim D

机构信息

Deparment of Chemistry, New York University, New York, NY, USA.

出版信息

Artif DNA PNA XNA. 2013 Jan-Mar;4(1):1-3. doi: 10.4161/adna.23892. Epub 2013 Jan 1.

Abstract

In their recent Science paper, Vafabakhsh and Ha claim that DNA duplexes at the range of 100 bp experience anomalous flexibility, much greater than the flexibility of large DNA molecules. ( 1) However, careful reevaluation of their data leads to the conclusion that the presented data do not warrant the authors' claim.

摘要

在他们最近发表于《科学》杂志的论文中,瓦法巴克什和哈声称,100个碱基对范围内的DNA双链体具有异常的柔韧性,远大于大型DNA分子的柔韧性。(1)然而,对他们的数据进行仔细重新评估后得出的结论是,所呈现的数据并不能支持作者的这一说法。

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本文引用的文献

1
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Science. 2012 Aug 31;337(6098):1097-101. doi: 10.1126/science.1224139.
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DNA curvature and flexibility in vitro and in vivo.
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Bending modes of DNA directly addressed by cryo-electron microscopy of DNA minicircles.
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Kinking the double helix by bending deformation.
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