Ha Sang Yun, Lee Yun Kyung, Oh Young Lyun
Department of Pathology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Acta Cytol. 2013;57(2):159-63. doi: 10.1159/000345103. Epub 2013 Feb 28.
The purpose of this study is to report our experience with the implementation of the ThinPrep Imaging System (TIS) in a tertiary hospital in Korea and to evaluate the effectiveness of the TIS compared to manual methods in the screening of cervical cytology.
Detection rates of cervical abnormalities in the pre- and post-TIS periods (January 2009 to February 2010 and March 2010 to December 2010, respectively) were compared. Follow-up cytological and histological results with concurrent or subsequent human papillomavirus (HPV) tests were retrieved.
ASC-US, ASC-H, LSIL, and HSIL were more frequently detected in the post-TIS period than in the pre-TIS period (p < 0.005). The proportions of correlated cases of ASC-US were 42.2 and 40.4% in the pre- and post-TIS periods, respectively. The detection rates of high-risk types of HPV in ASC-US were not significantly different between the two groups. The proportion of correlated biopsy for ASC-H, LSIL, and HSIL was similar in both periods. HPV positivity for ASC-H, LSIL, and HSIL showed no significant change between the two periods.
The TIS is potentially useful for the detection of abnormal cervical cytology on the basis of the increased detection rate of squamous cell abnormalities, with a relatively similar proportion of correlated cases compared to the manual screening method.
本研究旨在报告我们在韩国一家三级医院实施薄层液基细胞学成像系统（TIS）的经验，并评估TIS与手工方法相比在宫颈细胞学筛查中的有效性。
比较TIS实施前后（分别为2009年1月至2010年2月和2010年3月至2010年12月）宫颈异常的检出率。检索同时或随后进行人乳头瘤病毒（HPV）检测的后续细胞学和组织学结果。
TIS实施后，非典型鳞状细胞不能明确意义（ASC-US）、非典型鳞状细胞不排除高度病变（ASC-H）、低度鳞状上皮内病变（LSIL）和高度鳞状上皮内病变（HSIL）的检出频率高于实施前（p<0.005）。ASC-US相关病例的比例在TIS实施前和实施后分别为42.2%和40.4%。两组之间ASC-US中高危型HPV的检出率无显著差异。ASC-H、LSIL和HSIL相关活检的比例在两个时期相似。ASC-H、LSIL和HSIL的HPV阳性率在两个时期之间无显著变化。
基于鳞状细胞异常检出率的提高，TIS在检测宫颈细胞学异常方面可能有用，与手工筛查方法相比，相关病例的比例相对相似。
