Department of Chemistry, National University of Ireland Maynooth, Maynooth, Co. Kildare, Ireland.
Chem Commun (Camb). 2013 Mar 21;49(23):2341-3. doi: 10.1039/c3cc38710k.
1,10-Phenanthroline-5,6-dione and l-tyrosine methyl ester react to form phenanthroline-oxazine (PDT) from which Cu(PDT)(2)(2) and [Ag(PDT)(2)]ClO(4)·2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, Cu(phen)(2), the Cu(PDT)(2) complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.
1,10-菲咯啉-5,6-二酮和 l-酪氨酸甲酯反应生成菲咯嗪（PDT），由此得到Cu(PDT)(2)(2)和[Ag(PDT)(2)]ClO(4)·2MeOH。Ag(I)和 Cu(II) PDT 配合物与小牛胸腺 DNA 的结合超过了双-1,10-菲咯啉类似物和小沟结合药物，戊二脒和 netropsin。此外，与人工金属核酸酶Cu(phen)(2)不同，Cu(PDT)(2)配合物在加入还原剂的情况下不会切割 DNA，表明其与 DNA 的相互作用是独特的。
