FMRIB Centre, University of Oxford, Oxford OX1 2JD, United Kingdom.
J Neurosci. 2013 Feb 13;33(7):3190-201. doi: 10.1523/JNEUROSCI.2457-12.2013.
This article is a comparative study of white matter projections from ventral prefrontal cortex (vPFC) between human and macaque brains. We test whether the organizational rules that vPFC connections follow in macaques are preserved in humans. These rules concern the trajectories of some of the white matter projections from vPFC and how the position of regions in the vPFC dictate the trajectories of their projections in the white matter. To address this question, we present a novel approach that combines direct tracer measurements of entire white matter trajectories in macaque monkeys with diffusion MRI tractography of both macaques and humans. The approach allows us to provide explicit validation of diffusion tractography and transfer tractography strategies across species to test the extent to which inferences from macaques can be applied to human neuroanatomy. Apart from one exception, we found a remarkable overlap between the two techniques in the macaque. Furthermore, the organizational principles followed by vPFC tracts in macaques are preserved in humans.
这是一篇关于人类和猕猴大脑腹侧前额叶皮层（vPFC）白质投射的比较研究。我们测试了猕猴 vPFC 连接所遵循的组织规则是否在人类中得到保留。这些规则涉及到一些来自 vPFC 的白质投射的轨迹，以及 vPFC 中区域的位置如何决定它们在白质中的投射轨迹。为了解决这个问题，我们提出了一种新的方法，将猕猴整个白质轨迹的直接示踪测量与猕猴和人类的弥散磁共振成像追踪相结合。该方法允许我们对白质追踪技术进行明确验证，并在物种间进行转移追踪策略，以测试从猕猴推断出的结论在多大程度上可以应用于人类神经解剖学。除了一个例外，我们在猕猴中发现这两种技术之间有显著的重叠。此外，猕猴 vPFC 束遵循的组织原则在人类中得到了保留。
