Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Jpn J Ophthalmol. 2013 May;57(3):294-300. doi: 10.1007/s10384-013-0230-3. Epub 2013 Feb 14.
To evaluate changes in choroidal thickness adjacent to the area of laser application after photodynamic therapy (PDT) in patients with polypoidal choroidal vasculopathy (PCV) using enhanced depth imaging spectral-domain optical coherence tomography.
Masked observers measured the choroidal thickness at the subfovea and superior, inferior and temporal areas adjacent to the area of laser application before, 2 days, 1 week and 1 and 3 months after treatment.
Thirty-seven patients with PCV treated with PDT with verteporfin were included. The mean subfoveal choroidal thickness decreased significantly (P < 0.001) from 256 ± 115 μm at baseline to 207 ± 111 μm at 3 months; the mean outside choroidal thickness including the superior, inferior and temporal areas decreased significantly (P < 0.001) from 240 ± 92 μm at baseline to 209 ± 86 μm at 3 months.
PDT affected not only the subfoveal choroid, but also the choroid outside the area of laser application in PCV.
应用增强深度成像光谱域光学相干断层扫描（EDI-OCT）评估息肉样脉络膜血管病变（PCV）患者光动力疗法（PDT）后激光治疗区域周围脉络膜厚度的变化。
观察者对 37 例接受维替泊芬 PDT 治疗的 PCV 患者进行了研究，在治疗前、治疗后 2 天、1 周和 1、3 个月，分别对黄斑中心凹下、上方、下方和颞侧毗邻激光治疗区域的脉络膜厚度进行了测量。
256±115μm（基线）至 207±111μm（3 个月），黄斑中心凹下脉络膜厚度显著降低（P<0.001）；240±92μm（基线）至 209±86μm（3 个月），包括上方、下方和颞侧的周边脉络膜厚度显著降低（P<0.001）。
PDT 不仅影响黄斑中心凹下脉络膜，还影响 PCV 中激光治疗区域以外的脉络膜。
