Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum IPA, Bochum, Germany.
Allergy. 2013;68(5):580-4. doi: 10.1111/all.12120. Epub 2013 Feb 15.
Skin prick testing (SPT) in combination with the clinical history of the patient is one important step in the diagnosis of IgE-mediated occupational allergies. However, skin test performance is related to the quality of allergen extracts. The present consensus document was prepared by an EAACI Task Force consisting of an expert panel of allergologists and occupational physicians from Germany, Italy, Spain, France, Austria, and Poland. All members of the panel were also involved in the data collection within the European multicentre study STADOCA (Standard diagnosis for occupational allergy). The aim of this Task Force was the assessment of the quality of commercially available SPT solutions for selected occupational allergens under standardized procedure conditions in different European centres and institutes of Occupational Medicine. The data evaluation shows a wide variability among SPT solutions and also indicates that the sensitivity of several SPT solutions is low. Therefore, improvement and standardization of SPT solutions for occupational allergens is highly recommended. Clinical practitioners should also not presume that their SPT solutions are fully reliable. The main objective of the document is to issue consensus suggestions for the use of SPT with occupational allergens based on the European multicentre study STADOCA, on existing scientific evidence and the expertise of a panel of allergologists.
皮肤点刺试验（SPT）结合患者的临床病史是 IgE 介导的职业性过敏诊断的重要步骤之一。然而，皮肤试验的性能与过敏原提取物的质量有关。本共识文件由来自德国、意大利、西班牙、法国、奥地利和波兰的过敏专家和职业医生组成的 EAACI 工作组制定。该小组成员还参与了欧洲多中心 STADOCA（职业性过敏的标准诊断）研究中的数据收集。该工作组的目的是评估在不同的欧洲中心和职业医学研究所中，在标准化程序条件下，对选定的职业性过敏原的商业 SPT 解决方案的质量。数据评估显示 SPT 解决方案之间存在很大的可变性，也表明一些 SPT 解决方案的灵敏度较低。因此，强烈建议对职业性过敏原的 SPT 解决方案进行改进和标准化。临床医生也不应假定他们的 SPT 解决方案是完全可靠的。本文件的主要目的是根据欧洲多中心 STADOCA 研究、现有的科学证据和过敏专家小组的专业知识，就职业性过敏原的 SPT 使用提出共识建议。
