c-Met 外显子脱落与非小细胞肺癌中的 c-Met 表达相关。
Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer.
机构信息
Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China.
出版信息
Biomarkers. 2013 Mar;18(2):126-35. doi: 10.3109/1354750X.2012.751455.
OBJECTIVE
The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.
MATERIALS AND METHODS
We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.
RESULTS
Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.
目的
本研究旨在揭示非小细胞肺癌（NSCLC）患者中 c-Met 脱落与表达的相关性。
材料与方法
我们通过酶联免疫吸附试验和免疫组织化学法分别检测了一组临床前模型和 197 名中国晚期 NSCLC 患者中可溶性 c-Met 和 c-Met 水平。
结果
临床前模型中，可溶性 c-Met 的脱落与总 c-Met 量相关，且可溶性 c-Met 与人类的 c-Met 表达水平和肿瘤大小均相关，高可溶性 c-Met 预示着更差的预后。
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