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Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents.
Org Lett. 2013 Mar 1;15(5):1084-7. doi: 10.1021/ol400054m. Epub 2013 Feb 14.
2
Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study.
Phys Chem Chem Phys. 2016 Apr 14;18(14):9838-46. doi: 10.1039/c5cp07991h. Epub 2016 Mar 22.
3
Reversible inhibition of human acetylcholinesterase by methoxypyridinium species.
Bioorg Med Chem Lett. 2013 Nov 1;23(21):5786-9. doi: 10.1016/j.bmcl.2013.09.008. Epub 2013 Sep 8.
4
Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium--oximes.
J Enzyme Inhib Med Chem. 2004 Feb;19(1):39-43. doi: 10.1080/1475636031000163850.
5
A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds.
Chem Biol Interact. 2013 Mar 25;203(1):72-6. doi: 10.1016/j.cbi.2012.08.024. Epub 2012 Sep 12.
6
Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents.
J Biomol Struct Dyn. 2015 Sep;33(9):2048-58. doi: 10.1080/07391102.2014.989408. Epub 2014 Dec 18.
8
Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase.
Arch Toxicol. 2012 Sep;86(9):1379-86. doi: 10.1007/s00204-012-0842-2. Epub 2012 Mar 22.
9
Why is Aged Acetylcholinesterase So Difficult to Reactivate?
Molecules. 2017 Sep 4;22(9):1464. doi: 10.3390/molecules22091464.
10
Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes.
Environ Toxicol Pharmacol. 2019 Oct;71:103218. doi: 10.1016/j.etap.2019.103218. Epub 2019 Jul 5.

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Strategies for enhanced bioavailability of oxime reactivators in the central nervous system.
Arch Toxicol. 2023 Nov;97(11):2839-2860. doi: 10.1007/s00204-023-03587-0. Epub 2023 Aug 29.
2
Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase.
Chemistry. 2019 Apr 11;25(21):5337-5371. doi: 10.1002/chem.201805075. Epub 2019 Feb 13.
3
Stereoselective Dynamic Cyclization of Allylic Azides: Synthesis of Tetralins, Chromanes, and Tetrahydroquinolines.
J Am Chem Soc. 2018 Jan 31;140(4):1211-1214. doi: 10.1021/jacs.7b11299. Epub 2018 Jan 10.
4
Why is Aged Acetylcholinesterase So Difficult to Reactivate?
Molecules. 2017 Sep 4;22(9):1464. doi: 10.3390/molecules22091464.
5
Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase.
Ann N Y Acad Sci. 2016 Jun;1374(1):94-104. doi: 10.1111/nyas.13124. Epub 2016 Jun 21.

本文引用的文献

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Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents.
Acc Chem Res. 2012 May 15;45(5):756-66. doi: 10.1021/ar2002864. Epub 2012 Feb 23.
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Nonquaternary reactivators for organophosphate-inhibited cholinesterases.
J Med Chem. 2012 Jan 12;55(1):465-74. doi: 10.1021/jm201364d. Epub 2011 Dec 29.
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New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.
J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4.
4
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.
Chem Commun (Camb). 2011 May 14;47(18):5295-7. doi: 10.1039/c1cc10787a. Epub 2011 Mar 31.
5
Amidine-oximes: reactivators for organophosphate exposure.
J Med Chem. 2011 May 12;54(9):3319-30. doi: 10.1021/jm200054r. Epub 2011 Apr 11.
7
Structural approach to the aging of phosphylated cholinesterases.
Chem Biol Interact. 2010 Sep 6;187(1-3):157-62. doi: 10.1016/j.cbi.2010.03.027. Epub 2010 Mar 23.
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Excellent correlation between substituent constants and pyridinium N-methyl chemical shifts.
Tetrahedron Lett. 2009 Sep 2;50(35):5018-5020. doi: 10.1016/j.tetlet.2009.06.081.

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