Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Cancer Cell. 2013 Feb 11;23(2):131-2. doi: 10.1016/j.ccr.2013.01.009.
Use of the biguanide metformin, an AMPK activator, is associated with a reduced incidence of cancer in diabetics, but it has been unclear whether this requires AMPK. In this issue of Cancer Cell, Shackelford and colleagues show, paradoxically, that biguanides are more effective in the treatment of mouse tumors that lack a functional LKB1-AMPK pathway.
二甲双胍是一种 AMPK 激活剂，其在糖尿病人群中的应用与癌症发病率降低相关，但尚不清楚这是否需要 AMPK。在本期《癌细胞》杂志中，Shackelford 及其同事令人费解地表明，二甲双胍在缺乏功能性 LKB1-AMPK 通路的小鼠肿瘤的治疗中更有效。
