Imataka Hiromi, Sato Atsushi, Hamada Kazuyuki, Takeda Norikazu, Nemoto Hiroshi
Dept. of Medical Oncology, Showa University Hospital.
Gan To Kagaku Ryoho. 2013 Feb;40(2):241-3.
A 63-year-old- female was admitted to our hospital complaining of cough. Based on CT, bone centigram and peripheral blood findings, a diagnosis of gastric carcinoma accompanied by bone marrow metastasis was made. As DIC developed following hospital admission, S-1 and docetaxel(DOC)therapy was initiated(daily oral administration of 80 mg/m(2) S-1 for 14 days and DOC at 40 mg/m(2) on day 1, q3w). Recovery from DIC was achieved. S-1 and DOC therapy is considered to be effective for DIC due to bone marrow metastasis of gastric carcinoma. S-1/DOC is thought to be an effective chemotherapy against progressive gastric carcinoma accompanied by disseminated carcinomatosis bone marrow with DIC.
一名63岁女性因咳嗽入院。根据CT、骨摄片和外周血检查结果,诊断为胃癌伴骨髓转移。入院后发生弥散性血管内凝血(DIC),遂开始使用S-1和多西他赛(DOC)治疗(S-1每日口服80mg/m²,共14天,DOC于第1天给予40mg/m²,每3周一次)。DIC得到缓解。S-1和DOC治疗被认为对胃癌骨髓转移所致DIC有效。S-1/DOC被认为是治疗进展期胃癌伴播散性癌病骨髓转移合并DIC的有效化疗方案。