Ganno Hideaki, Nagahama Takeshi, Fukuda Akira, Takeuchi Shoko, Fujiya Keiichi, Amagasa Hidetoshi, Kamikozuru Hirotaka, Imai Kenichiro, Ami Katsunori, Aoki Nobuhiko, Ando Masayuki, Arai Kuniyoshi, Tei Shikofumi, Ohbu Masahide
Dept. of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital.
Gan To Kagaku Ryoho. 2013 Nov;40(12):2241-3.
We report a case of gastric cancer accompanied by disseminated carcinomatosis of the bone marrow treated with S-1 and cisplatin( CDDP) combination chemotherapy. The patient was a 68-year-old woman who was detected as having disseminated intravascular coagulation( DIC) during an examination for gastric cancer and she was diagnosed as having disseminated carcinomatosis of the bone marrow by lumbar puncture. She was immediately treated with S-1 and CDDP combination chemotherapy( S-1, 80 mg/body orally administered[ po] on days 1-21 and CDDP, 60 mg/body intravenously [iv] administered on day 8) and her DIC improved on the fourth day. Subsequently, the patient was treated with 3 courses of combination chemotherapy and she survived for 184 days from the initiation of the treatment. Although disseminated carcinomatosis of the bone marrow is associated with a poor prognosis, we believe that the duration of survival of our patient was extended due to initiation of chemotherapy at an early stage.
我们报告了一例胃癌伴骨髓播散性癌病患者，接受了S-1和顺铂（CDDP）联合化疗。患者为一名68岁女性，在胃癌检查期间被检测出患有弥散性血管内凝血（DIC），经腰椎穿刺诊断为骨髓播散性癌病。她立即接受了S-1和CDDP联合化疗（S-1，80mg/体，口服，第1 - 21天；CDDP，60mg/体，静脉注射，第8天），DIC在第4天得到改善。随后，患者接受了3个疗程的联合化疗，从治疗开始存活了184天。尽管骨髓播散性癌病预后较差，但我们认为该患者的生存期延长是由于早期开始化疗。
