益生菌与坏死性小肠结肠炎：探寻益生菌谜题中缺失的环节
Probiotics and necrotizing enterocolitis: finding the missing pieces of the probiotic puzzle.
作者信息
Luedtke Sherry A, Yang Jacob T, Wild Heather E
机构信息
Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas.
出版信息
J Pediatr Pharmacol Ther. 2012 Oct;17(4):308-28. doi: 10.5863/1551-6776-17.4.308.
Abstract
Necrotizing enterocolitis (NEC) is one of the leading causes of death in the neonatal intensive care unit. Morbidity and mortality rates significantly increase with decreases in gestational age and birth weight. Strong evidence suggests probiotic prophylaxis may significantly decrease the incidence of NEC and should therefore be incorporated into the standard of care for preterm infants. However, debate still remains because of limitations of completed studies. The purpose of this review was to provide an overview of the controversies regarding probiotic use in preterm infants and to shed light on the practical considerations for implementation of probiotic supplementation.
摘要
坏死性小肠结肠炎（NEC）是新生儿重症监护病房主要的死亡原因之一。发病率和死亡率会随着胎龄和出生体重的降低而显著增加。有力证据表明，预防性使用益生菌可能会显著降低NEC的发病率，因此应纳入早产儿的标准护理中。然而，由于已完成研究存在局限性，相关争论仍然存在。本综述的目的是概述关于早产儿使用益生菌的争议，并阐明实施益生菌补充的实际考虑因素。
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