Laboratory of Reproductive Neuroendocrinology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
Metabolism. 2013 Jul;62(7):898-910. doi: 10.1016/j.metabol.2013.01.015. Epub 2013 Feb 13.
Changes in metabolic status gate reproductive activity by still incompletely deciphered mechanisms. Many neuropeptides have been shown to be involved in restraining hypothalamic gonadotropin releasing hormone (GnRH) release under conditions of negative energy balance. Broadly, on the basis of their effect on feeding, these can be grouped as orexigenic and anorexigenic neuropeptides. Reciprocally correlated, in response to changes in systemic concentrations of metabolic hormones, the secretion of orexigenic neuropeptides increases while that of anorexigenic neuropeptides decreases during conditions of food restriction. Recently, kisspeptin signaling in hypothalamus has appeared as a pivotal regulator of the GnRH pulse generator. Kisspeptin apparently does not affect feeding, but in light of accumulating data, it has emerged as one of the major conduits in relaying body metabolic status information to GnRH neurons. The present review examines such data obtained from rodent and primate models, which suggest kisspeptin-Kiss1r signaling as a possible pathway providing a link between metabolism and reproduction.
代谢状态的变化通过仍然不完全破译的机制来控制生殖活动。许多神经肽已被证明在负能平衡条件下可抑制下丘脑促性腺激素释放激素（GnRH）的释放。基于它们对摄食的影响，这些神经肽可大致分为食欲肽和厌食神经肽。相反，为了响应代谢激素在全身浓度上的变化，在食物限制期间，食欲肽的分泌增加，而厌食神经肽的分泌减少。最近，下丘脑中的 kisspeptin 信号似乎是 GnRH 脉冲发生器的关键调节因子。Kisspeptin 显然不影响摄食，但鉴于越来越多的数据，它已成为将身体代谢状态信息传递给 GnRH 神经元的主要途径之一。本综述检查了从啮齿动物和灵长类动物模型中获得的此类数据，这些数据表明 kisspeptin-Kiss1r 信号可能是提供代谢与生殖之间联系的途径之一。
