Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, UMR-S975, Paris, France.
Trends Cogn Sci. 2013 Mar;17(3):102-4. doi: 10.1016/j.tics.2013.01.005. Epub 2013 Feb 13.
Patients who confabulate have at least partially preserved hippocampus and make confabulatory errors in remembering their past, in orienting themselves in time and space, and in predicting their personal future. Conversely, complete bilateral hippocampal damage produces deep amnesia, temporo-spatial disorientation, and inability to predict the personal future. We propose that the hippocampus is the neural correlate of 'temporal consciousness', which is lost in amnesia and present, but malfunctioning in confabulation.
虚构症患者的海马体至少部分保留,他们在回忆过去、在时间和空间上定向以及预测个人未来时会出现虚构错误。相反,双侧海马体完全损伤会导致严重的遗忘、时间和空间定向障碍以及无法预测个人未来。我们提出,海马体是“时间意识”的神经相关物,在遗忘症中丧失,在虚构症中存在但功能失调。