Department of Neuroscience, University of Georgia, Athens, Georgia 30602, USA.
Psychophysiology. 2013 Apr;50(4):325-33. doi: 10.1111/psyp.12030. Epub 2013 Feb 19.
Cognitive control is required for correct antisaccade performance. High antisaccade error rates characterize certain psychiatric disorders, but can be highly variable, even among healthy groups. Antisaccade data were acquired from a large sample of healthy undergraduates, and error rate was quantified. Participants who reliably made few errors (good, n = 13) or many errors (poor, n = 13) were recruited back to perform antisaccades during fMRI acquisition. A data-derived model was used to compare signal between good and poor performers during blocks of antisaccade trials. Behaviorally derived regressors were used to compare signal between good and poor performers during correct and error trials. Results show differential activation in middle frontal gyrus and inferior parietal lobule between good and poor performers, suggesting that failure to recruit these top-down control regions corresponds to poor antisaccade performance in healthy young adults.
认知控制是正确反扫视表现所必需的。高反扫视错误率是某些精神疾病的特征，但即使在健康人群中，错误率也可能高度可变。反扫视数据来自大量健康大学生的样本，并对错误率进行了量化。招募了一些可靠地犯少量错误（好，n = 13）或大量错误（差，n = 13）的参与者在 fMRI 采集期间进行反扫视。使用数据衍生模型比较了反扫视试验块中表现良好者和表现不佳者之间的信号。使用行为衍生回归器比较了正确和错误试验中表现良好者和表现不佳者之间的信号。结果表明，在表现良好者和表现不佳者之间，中额回和下顶叶回存在差异激活，这表明未能招募这些自上而下的控制区域与健康年轻成年人的反扫视表现不佳相对应。
