Department of Children's Health Care, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Maternal and Child Health Care Hospital, Nanjing, Jiangsu, China.
Physiol Res. 2024 Apr 30;73(2):205-216. doi: 10.33549/physiolres.935202.
ADHD is a common chronic neurodevelopmental disorder and is characterized by persistent inattention, hyperactivity, impulsivity and are often accompanied by learning and memory impairment. Great evidence has shown that learning and memory impairment of ADHD plays an important role in its executive function deficits, which seriously affects the development of academic, cognitive and daily social skills and will cause a serious burden on families and society. With the increasing attention paid to learning and memory impairment in ADHD, relevant research is gradually increasing. In this article, we will present the current research results of learning and memory impairment in ADHD from the following aspects. Firstly, the animal models of ADHD, which display the core symptoms of ADHD as well as with learning and memory impairment. Secondly, the molecular mechanism of has explored, including some neurotransmitters, receptors, RNAs, etc. Thirdly, the susceptibility gene of ADHD related to the learning and impairment in order to have a more comprehensive understanding of the pathogenesis. Key words: Learning and memory, ADHD, Review.
注意缺陷多动障碍(ADHD)是一种常见的慢性神经发育障碍,其特征为持续的注意力不集中、多动、冲动,并且常伴有学习和记忆障碍。大量证据表明,ADHD 的学习和记忆障碍在其执行功能缺陷中起着重要作用,这严重影响了学业、认知和日常社交技能的发展,并会给家庭和社会带来严重负担。随着对 ADHD 中学习和记忆障碍的关注度不断提高,相关研究也在逐渐增加。本文将从以下几个方面综述 ADHD 中学习和记忆障碍的研究进展:首先,展示具有 ADHD 核心症状和学习记忆障碍的 ADHD 动物模型;其次,探讨与学习记忆障碍相关的分子机制,包括一些神经递质、受体、RNAs 等;最后,探讨与 ADHD 相关的学习和记忆障碍的易感基因,以便更全面地了解发病机制。关键词:学习和记忆;ADHD;综述。