German Cancer Research Center, Peptide Synthesis Core Facility, INF 280, D-69120 Heidelberg, Germany.
Int J Med Sci. 2013;10(3):331-7. doi: 10.7150/ijms.5374. Epub 2013 Feb 13.
The personalized medicine, also documented as "individualized medicine", is an effective and therapeutic approach. It is designed to treat the disease of the individual patient whose precise differential gene expression profile is well known. The trend in the biomedical and biophysical research shows important consequences for the pharmaceutical drug and diagnostics research. It requires a high variability in the design and safety of target-specific pharmacologically active molecules and diagnostic components for imaging of metabolic processes. A key technology which may fulfill the highest demands during synthesis of these individual drugs and diagnostics is the solid phase synthesis which is congenial to automated manufacturing. Additionally the choice of tools like resins and reagents is pivotal to synthesize drugs and diagnostics in high quality and yields. Here we demonstrate the solid phase synthesis effects dependent on the choice of resin and of the deprotection agent.
个体化医学，也被记录为“个性化医学”，是一种有效的治疗方法。它旨在治疗个体患者的疾病，这些患者的精确差异基因表达谱是已知的。生物医学和生物物理学研究的趋势对药物和诊断研究产生了重要影响。它需要在设计和安全性方面具有高度的变异性，以针对特定的药理活性分子和代谢过程成像的诊断组件。在这些个体化药物和诊断的合成过程中，一种可能满足最高要求的关键技术是固相合成，它适合自动化制造。此外，选择合适的树脂和试剂对于高质量和高产率地合成药物和诊断也至关重要。在这里，我们展示了基于树脂和脱保护剂选择的固相合成效果。
