Student of Peking Union Medical Collegel, Peking Union Medical College Hospital, Beijing, China.
Clin Nucl Med. 2013 Apr;38(4):248-51. doi: 10.1097/RLU.0b013e3182817c31.
Thyrotoxic periodic paralysis (TPP) is a complication of thyrotoxicosis mainly observed in male Asian patients. It was proposed that patients with TPP tend to have lower thyroid hormone levels. We aimed to prove this observation and to assess whether a lower I dose is feasible for prompt control of TPP.
A total of 123 male TPP patients were enrolled in this study in a 7-year period. Baseline characteristics were compared with 70 thyrotoxic patients without periodic paralysis (nTPP). Different I doses were given to 90 TPP patients with a median follow-up of 11 months, and the outcome was evaluated.
The serum thyroid hormone levels, including total T3 and T4, and free T3 and T4, in TPP patients were slightly less elevated compared with those in nTPP patients. Patients who received lower radioactivity of I had an unsatisfactory overall remission rate of 28.6%. Longer time to remission (P = 0.004; hazard ratio, 1.846; 95% confidence interval, 1.216-2.798) was also observed in patients with lower dose.
The serum thyroid hormone levels of TPP patients are lower than those of nTPP patients. Median/high dose of I is necessary to achieve rapid control of thyrotoxicosis.
甲状腺毒症周期性瘫痪（TPP）是甲状腺毒症的一种并发症，主要见于男性亚洲患者。有人提出，TPP 患者的甲状腺激素水平往往较低。我们旨在验证这一观察结果，并评估较低剂量的碘是否可行以迅速控制 TPP。
本研究在 7 年期间共纳入 123 例男性 TPP 患者。将基线特征与 70 例无周期性瘫痪的甲状腺毒症患者（nTPP）进行比较。对 90 例 TPP 患者给予不同剂量的碘，中位随访时间为 11 个月，评估结果。
与 nTPP 患者相比，TPP 患者的血清甲状腺激素水平（包括总 T3 和 T4 以及游离 T3 和 T4）略低。接受较低放射性碘治疗的患者总体缓解率不理想，为 28.6%。较低剂量组的缓解时间也更长（P = 0.004；风险比，1.846；95%置信区间，1.216-2.798）。
TPP 患者的血清甲状腺激素水平低于 nTPP 患者。中/高剂量碘是迅速控制甲状腺毒症所必需的。
