Department of Endocrinology and Metabolism, Xijing Hospital, The Fourth Military Medical University, Xi'an Shaanxi 710032, China.
Endocrine. 2010 Dec;38(3):386-90. doi: 10.1007/s12020-010-9396-3. Epub 2010 Oct 23.
Our study is to determine the expression of thyroid hormone, sex hormone, insulin, and C-peptide in Chinese male patients with thyrotoxic periodic paralysis (TPP). This study covered 102 patients with hyperthyroidism from Xijing Hospital. According to whether occurrence of TPP or not, patients were divided into two groups (those that were hyperthyroid with and without TPP) that were, matched with age, blood pressure, urea, and creatinine. We found the body mass index (BMI) in patients with TPP was higher than that in pure hyperthyroidism patients. The levels of the total thyroxine (T4), free triiodothyronine (FT3), and free thyroxine (FT4) were significantly lower in patients with TPP compared with pure hyperthyroidism patients, while serum testosterone levels were higher compared with pure hyperthyroidism patients. Moreover, after glucose administration, the concentration of insulin at 60, 120, and 180 min were significantly higher in patients with TPP than those in pure hyperthyroidism patients. The insulin area under the curve (AUC) was significantly increased in patients with TPP compared with pure hyperthyroidism patients. The levels of thyroid hormone, sex hormone, and insulin were different in Chinese male patients with TPP compared to those with only hyperthyroidism.
我们的研究旨在确定甲状腺激素、性激素、胰岛素和 C 肽在患有甲状腺毒性周期性麻痹（TPP）的中国男性患者中的表达。这项研究涵盖了来自西京医院的 102 名甲状腺功能亢进症患者。根据是否发生 TPP，将患者分为两组（伴有和不伴有 TPP 的甲状腺功能亢进症患者），两组在年龄、血压、尿素和肌酐方面相匹配。我们发现 TPP 患者的体重指数（BMI）高于单纯甲状腺功能亢进症患者。与单纯甲状腺功能亢进症患者相比，TPP 患者的总甲状腺素（T4）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）水平明显降低，而血清睾丸酮水平则高于单纯甲状腺功能亢进症患者。此外，葡萄糖给药后，TPP 患者的胰岛素在 60、120 和 180 分钟时的浓度明显高于单纯甲状腺功能亢进症患者。TPP 患者的胰岛素曲线下面积（AUC）明显高于单纯甲状腺功能亢进症患者。与单纯甲状腺功能亢进症患者相比，中国男性 TPP 患者的甲状腺激素、性激素和胰岛素水平存在差异。
