Inflamm Bowel Dis. 2013 Mar;19(3):548-9. doi: 10.1097/MIB.0b013e318281ce99.
Although abundant indirect evidence suggests that environmental factors contribute to the pathogenesis of inflammatory bowel disease (IBD), the search for specific etiological agents has been largely disappointing. Early life factors have been hypothesized to influence the risk of IBD; however, new data from the Nurses Health Study showed no associations between breastfeeding, gestational age, and birthweight and adult-onset IBD.
虽然大量间接证据表明环境因素有助于炎症性肠病 (IBD) 的发病机制,但寻找特定的病因一直令人大失所望。人们曾假设生命早期的因素会影响 IBD 的风险;然而,来自护士健康研究的新数据表明,母乳喂养、胎龄和出生体重与成人发病的 IBD 之间没有关联。