ADHD Outpatient Program, Universidade Federal do Rio Grande do Sul, Brazil.
Braz J Psychiatry. 2012 Oct;34(3):321-8. doi: 10.1016/j.rbp.2012.01.001.
The objective of the present study is to investigate the association between attention deficit/hyperactivity disorder (ADHD), predominantly inattentive type (ADHD-I) and prenatal, delivery and early postnatal complications (PDPC).
In a case-control design, we assessed a sample of 124 children and adolescents with ADHD-I and 124 non-ADHD controls (6-17 years old) from both a non-referred (n = 200) and a clinical sample (n = 48). Cases and controls, matched by gender and age, were systematically evaluated through structured diagnostic interviews. Prenatal, delivery and early postnatal complications (PDPC), as well as potential confounders were evaluated by direct interview with biological mothers.
Conditional logistic regression analysis showed that children and adolescents whose mothers presented more PDPC had a significantly higher risk for ADHD-I (p = 0.005; OR = 1.25; CI 95%: 1.1-1.5).
In a case-control study, we expanded to ADHD-I previous findings suggesting the association between perinatal factors and broadly defined ADHD. Due to the preventable nature of some of these PDPC, our results have clear impact in public mental health policies.
本研究旨在探讨注意力缺陷多动障碍（ADHD），主要为注意力不集中型（ADHD-I）与产前、分娩和产后早期并发症（PDPC）之间的关系。
采用病例对照设计，我们评估了 124 名 ADHD-I 患儿和青少年及 124 名非 ADHD 对照组（6-17 岁），均来自非转诊组（n=200）和临床组（n=48）。病例和对照组按性别和年龄匹配，通过结构化诊断访谈进行系统评估。通过对生物母亲的直接访谈，评估了产前、分娩和产后早期并发症（PDPC）以及潜在的混杂因素。
条件逻辑回归分析显示，母亲有更多 PDPC 的儿童和青少年患 ADHD-I 的风险显著更高（p=0.005；OR=1.25；95%CI：1.1-1.5）。
在病例对照研究中，我们扩展了之前关于围产期因素与广义 ADHD 之间关系的发现，进一步证实了 ADHD-I 与 PDPC 之间的关系。由于这些 PDPC 中的一些具有可预防性，因此我们的研究结果对公共精神卫生政策具有明确的影响。
