人类输精管中肾上腺素能传递的进一步证据。
Further evidence for adrenergic transmission in the human vas deferens.
作者信息
Anton P G, McGrath J C
出版信息
J Physiol. 1977 Dec;273(1):45-55. doi: 10.1113/jphysiol.1977.sp012080.
Abstract
- Isolated portions of human vas deferens responded to field stimulation of the intramural nerve fibres or to exogenously applied noradrenaline with rhythmical contractions of both longitudinal and circular muscle layers. 2. In guinea-pig and rabbit vas deferens field stimulation produced an initial rapid 'twitch' response which was not found with human vasa. 3. Responses of the human vas to field stimulation were depressed by the alpha-adrenoceptor blocking agents phentolamine and yohimbine. 4. It is concluded that the motor innervation of the human vas deferens is adrenergic and the relevance of this to the physiological operation of the tissue is discussed.
摘要
- 分离出的人体输精管部分对壁内神经纤维的场刺激或对外源性应用的去甲肾上腺素产生反应，表现为纵行和环形肌层的节律性收缩。2. 在豚鼠和兔的输精管中，场刺激会产生最初的快速“抽搐”反应，而人体输精管未发现这种反应。3. α-肾上腺素能受体阻断剂酚妥拉明和育亨宾可抑制人体输精管对场刺激的反应。4. 得出结论：人体输精管的运动神经支配是肾上腺素能的，并讨论了其与该组织生理功能的相关性。
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