Department of Psychology, University of Haifa, Haifa 31905, Israel.
Schizophr Res. 2013 May;146(1-3):357-62. doi: 10.1016/j.schres.2013.01.006. Epub 2013 Feb 19.
Previous research has shown that patients with schizophrenia are impaired in a wide range of social cognitive abilities, including emotion recognition, empathy for others, and mental perspective-taking. Recent studies suggest that a dysfunction of the oxytocinergic system contributes to the social impairment in schizophrenia. Accordingly, the present study sought to examine whether patients with schizophrenia would improve in a social perception task after taking a single dose of oxytocin, as compared to a placebo. Thirty-five patients diagnosed with schizophrenia were compared with 46 psychologically healthy matched controls on their recognition of kinship and intimacy, using the Interpersonal Perception Task. All participants received a single intranasal dose of 24 IU oxytocin or placebo, one week apart. Overall, the participants were more accurate in judging intimacy and kinship following the administration of oxytocin, as opposed to a placebo. However, when comparing patients with controls, only the recognition of kinship improved significantly in the patient group, whereas no such effect was observed in the control group or in the recognition of intimacy in either group. This is one of the first studies to demonstrate that social perception in schizophrenia can be improved by the administration of oxytocin and that patients show a greater treatment effect than controls.
先前的研究表明，精神分裂症患者在广泛的社会认知能力方面存在障碍，包括情绪识别、对他人的同理心和心理视角-taking。最近的研究表明，催产素能系统的功能障碍导致精神分裂症的社交障碍。因此，本研究旨在探讨精神分裂症患者在单次接受催产素治疗后，是否会在社会感知任务中得到改善，与安慰剂相比。使用人际关系感知任务，将 35 名被诊断为精神分裂症的患者与 46 名心理健康匹配的对照组进行了亲缘关系和亲密关系的识别比较。所有参与者在一周的间隔内分别接受 24IU 催产素或安慰剂的单次鼻内给药。总的来说，与安慰剂相比，参与者在给予催产素后更准确地判断了亲密关系和亲属关系。然而，当将患者与对照组进行比较时，只有亲属关系的识别在患者组中显著改善，而对照组或两组的亲密关系识别均未观察到这种效果。这是首次证明精神分裂症患者的社会知觉可以通过催产素的给予得到改善，并且患者的治疗效果大于对照组的研究之一。
