Strauss Gregory P, Keller William R, Koenig James I, Sullivan Sara K, Gold James M, Buchanan Robert W
State University of New York at Binghamton, Department of Psychology, USA.
University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, USA.
Schizophr Res. 2015 Mar;162(1-3):52-6. doi: 10.1016/j.schres.2015.01.022. Epub 2015 Jan 22.
Lower endogenous oxytocin levels have been associated with impaired social cognition in schizophrenia, particularly facial affect identification. Little is known about the relationship between oxytocin and other forms of emotion perception. In the current study, 41 individuals with schizophrenia (SZ) and 22 demographically matched healthy controls (CN) completed a forced-choice affective body expression classification task. Stimuli included dynamic videos of male and female actors portraying 4 discrete emotions: happiness, sadness, anger, and neutral. Plasma oxytocin levels were determined via radioimmunoassay. Results indicated that SZ had significantly higher plasma oxytocin concentrations than CN. SZ were also less accurate at identifying expressions of happiness and sadness; however, there were no group differences for anger or neutral stimuli. A group×sex interaction was also present, such that female CN were more accurate than male CN, whereas male SZ were more accurate than female SZ. Higher endogenous oxytocin levels were associated with better total recognition in both SZ and CN; this association was specific to females in SZ. Findings indicate that sex plays an important role in identifying emotional expressions in body gestures in SZ, and that individual differences in endogenous oxytocin predict emotion perception accuracy.
内源性催产素水平较低与精神分裂症患者社会认知受损有关，尤其是面部情感识别方面。关于催产素与其他形式情感感知之间的关系，人们知之甚少。在本研究中，41名精神分裂症患者（SZ）和22名人口统计学匹配的健康对照者（CN）完成了一项强制选择情感身体表达分类任务。刺激物包括男性和女性演员描绘4种不同情绪（快乐、悲伤、愤怒和中性）的动态视频。通过放射免疫测定法测定血浆催产素水平。结果表明，SZ的血浆催产素浓度显著高于CN。SZ在识别快乐和悲伤表情方面也不太准确；然而，在愤怒或中性刺激方面，两组没有差异。还存在组×性别的交互作用，即女性CN比男性CN更准确，而男性SZ比女性SZ更准确。较高的内源性催产素水平与SZ和CN中更好的总体识别能力相关；这种关联在SZ中特定于女性。研究结果表明，性别在SZ识别身体姿势中的情感表达方面起着重要作用，并且内源性催产素的个体差异可预测情感感知准确性。
