Department of Molecular Biology, Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Curr Opin Microbiol. 2013 Feb;16(1):70-7. doi: 10.1016/j.mib.2013.02.002. Epub 2013 Feb 22.
Vibrio parahaemolyticus is a marine microorganism that causes acute gastroenteritis associated with the consumption of contaminated raw or under cooked seafood. During infection, the bacterium utilizes a wide variety of virulence factors, including adhesins, toxins and type III secretion systems, to cause both cytotoxicity in cultured cells and enterotoxicity in animal models. Herein, we describe recent discoveries on the regulation and characterization of the virulence factors from V. para. Determining how this bacterial pathogen uses virulence factors to mediate pathogenicity improves our understanding of V. para. infections and more generally, host-pathogen interactions.
副溶血性弧菌是一种海洋微生物，可导致与食用受污染的生的或未煮熟的海鲜有关的急性肠胃炎。在感染过程中，该细菌利用多种毒力因子，包括黏附素、毒素和 III 型分泌系统，引起培养细胞的细胞毒性和动物模型的肠毒性。本文描述了副溶血性弧菌毒力因子的调控和特性的最新发现。确定这种细菌病原体如何利用毒力因子来介导致病性，可提高我们对副溶血性弧菌感染的理解，更广泛地说，还可提高我们对宿主-病原体相互作用的理解。
