Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Neurobiol Aging. 2013 Jul;34(7):1846-52. doi: 10.1016/j.neurobiolaging.2013.01.011. Epub 2013 Feb 22.
Cytomegalovirus infection has been implicated in cognitive impairment in studies using brief clinical assessments though findings are inconsistent. The association between cytomegalovirus infection, measured as serostatus or a semiquantitative assessment of antibody level, and cognitive abilities in a sample of older adults was examined. Cytomegalovirus status was assessed at a mean age of 70 years in 1061 participants of the Lothian Birth Cohort 1936. Cognitive ability scores were available for general cognitive ability, processing speed, memory, and vocabulary. Background demographic and environmental factors included father's social class, years of education, childhood cognitive ability, overcrowding in childhood, and access to indoor toilet facilities. Cytomegalovirus seropositive individuals had lower cognitive ability at age 70: mean IQ was 99.1 (SD, 15.1) versus 102.4 (SD, 13.1) in seronegative individuals (t = 3.65; p < 0.001). The likelihood of contracting cytomegalovirus infection by age 70 was predicted by a number of demographic and environmental factors and, after accounting for these, cytomegalovirus infection (considered as serostatus) was not cognitively detrimental. Within cytomegalovirus seropositive individuals, however, higher cytomegalovirus antibody levels were associated with lower general cognitive ability.
巨细胞病毒感染与认知障碍有关，这在使用简短临床评估的研究中得到了证实，但研究结果并不一致。本研究旨在探讨老年人样本中巨细胞病毒感染（以血清学状态或抗体水平的半定量评估来衡量）与认知能力之间的关系。在爱丁堡 1936 年出生队列的 1061 名参与者中，于平均年龄为 70 岁时评估巨细胞病毒状态。认知能力评分可用于评估一般认知能力、处理速度、记忆和词汇量。背景人口统计学和环境因素包括父亲的社会阶层、受教育年限、儿童期认知能力、儿童时期的拥挤程度以及使用室内厕所设施的情况。巨细胞病毒血清阳性个体在 70 岁时的认知能力较低：血清阴性个体的平均智商为 99.1（标准差，15.1），而血清阳性个体为 102.4（标准差，13.1）（t=3.65；p<0.001）。到 70 岁时感染巨细胞病毒的可能性受多种人口统计学和环境因素的预测，在考虑到这些因素后，巨细胞病毒感染（以血清学状态来衡量）并没有对认知能力造成损害。然而，在巨细胞病毒血清阳性个体中，较高的巨细胞病毒抗体水平与较低的一般认知能力相关。
