Sarkar Siddharth, Nebhinani Naresh, Singh Shubh M, Mattoo Surendra K, Basu Debasish
Department of Psychiatry, Drug De-addiction Treatment Centre, PGIMER, Chandigarh, India.
Indian J Psychol Med. 2012 Jul;34(3):283-5. doi: 10.4103/0253-7176.106038.
Tramadol is an atypical, centrally acting, synthetic analgesic, acting through opioid and non-opioid systems. We present a series of seven cases, all men, who sought treatment at our centre for tramadol-dependence. The majority were using other opioids at some point in their lives. Their tramadol use had begun with a prescription of tramadol for opioid detoxification, for headache and body pains, and as an alternative to injectable opioids. The doses of tramadol used varied from 50 to 1500 mg per day. All subjects reported an experience of euphoria with tramadol use. Four patients were put on naltrexone, but had poor compliance. This case series underscores the need for caution, while using tramadol in substance-dependent patients.
曲马多是一种非典型的、作用于中枢的合成镇痛药，通过阿片类和非阿片类系统发挥作用。我们报告了一系列7例病例，均为男性，他们在我们中心寻求曲马多依赖的治疗。大多数人在生活中的某个阶段还使用过其他阿片类药物。他们开始使用曲马多是用于阿片类药物脱毒的处方、治疗头痛和身体疼痛，以及作为注射用阿片类药物的替代品。曲马多的使用剂量为每天50至1500毫克。所有受试者均报告使用曲马多后有欣快感。4例患者服用了纳曲酮，但依从性较差。该病例系列强调了在物质依赖患者中使用曲马多时需谨慎。
