Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA; Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
J Magn Reson Imaging. 2013 Nov;38(5):1129-39. doi: 10.1002/jmri.24070. Epub 2013 Feb 25.
To evaluate the correlation between angiographic measures of Moyamoya disease and tissue-level impairment from measurements of tissue perfusion and cerebrovascular reactivity (CVR).
The relationship between perfusion-weighted arterial spin labeling (ASL) and hypercarbic blood oxygenation-level dependent (BOLD) CVR and time-to-peak (TTP) were compared with angiographically measured risk factors, including arterial circulation time (ACT) and modified Suzuki Score (mSS) in patients (n = 15) with Moyamoya disease.
Hemodynamic contrasts provided information not apparent from structural or angiographic imaging. Mean z-statistics demonstrate that BOLD is significantly (P = 0.017) higher in low mSS hemispheres (z-statistic = 5.0 ± 2.5) compared with high mSS hemispheres (z-statistic = 3.7 ± 1.7), suggesting that regions with less advanced stages of Moyamoya disease have higher reactivity. After correcting for multiple comparisons, a strong trend for a direct relationship (R = 0.38; P = 0.03) between BOLD TTP and ACT was observed, and a significant inverse relationship between CBF and ACT (R = -0.47; P = 0.01) was found, demonstrating that BOLD and ASL contrasts reflect DSA measures of vascular compromise in Moyamoya disease, albeit with different sensitivity.
Correlative measures between angiography and hemodynamic methods suggest that BOLD and ASL could be used for expanding the diagnostic imaging infrastructure in Moyamoya patients and potentially tracking tissue response to revascularization.
评估烟雾病血管造影测量指标与组织灌注和脑血管反应性（CVR）的组织水平损害之间的相关性。
对比分析灌注加权动脉自旋标记（ASL）和高碳酸血症血氧水平依赖（BOLD）CVR 与时间至峰值（TTP）与血管造影测量的危险因素（包括动脉循环时间（ACT）和改良 Suzuki 评分（mSS））之间的关系，在患有烟雾病的患者（n = 15）中。
血流动力学对比提供了结构或血管造影成像不明显的信息。平均 z 统计量表明，低 mSS 半球的 BOLD 明显更高（z 统计量 = 5.0 ± 2.5）与高 mSS 半球（z 统计量 = 3.7 ± 1.7），表明血管病变较轻的区域反应性更高。在进行多重比较校正后，观察到 BOLD TTP 和 ACT 之间存在直接关系的强烈趋势（R = 0.38；P = 0.03），并且 CBF 和 ACT 之间存在显著的负相关关系（R = -0.47；P = 0.01），表明 BOLD 和 ASL 对比反映了烟雾病中血管损害的 DSA 测量，但敏感性不同。
血管造影和血液动力学方法之间的相关测量表明，BOLD 和 ASL 可用于扩展烟雾病患者的诊断成像基础设施，并可能跟踪组织对血管重建的反应。
