Tomioka H, Sato K, Saito H
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Japan.
Antimicrob Agents Chemother. 1990 Apr;34(4):632-6. doi: 10.1128/AAC.34.4.632.
Multiple injections of ofloxacin (subcutaneous or oral) in combination with a Lactobacillus casei preparation, LC9018 (subcutaneous), in mice infected intravenously with Mycobacterium fortuitum led to a marked delay in the incidence of spinning disease, a lowered incidence of gross renal lesions, and an increase in the rate of elimination of organisms from the kidneys. This indicates synergism in the therapeutic efficacy of the two agents. When the antimicrobial ability of peritoneal macrophages (M phi s) against M. fortuitum was measured in medium with or without ofloxacin, growth of the organisms was more markedly inhibited by ofloxacin in LC9018-induced M phi s than in normal M phi s. Synergism in the therapeutic activity of oxfloxacin plus LC9018 is assumed to be mediated in part by host M phi s, that is, functional stimulation of host M phi s by LC9018 treatment results in the synergistic effects of the two agents.
对静脉注射偶然分枝杆菌感染的小鼠，多次皮下或口服注射氧氟沙星，并联合皮下注射干酪乳杆菌制剂LC9018，可显著延迟旋转病的发病，降低肾脏肉眼可见病变的发生率，并提高从肾脏清除细菌的速率。这表明两种药物在治疗效果上具有协同作用。当在含或不含氧氟沙星的培养基中测定腹腔巨噬细胞（M phi s）对偶然分枝杆菌的抗菌能力时，在LC9018诱导的M phi s中，氧氟沙星对细菌生长的抑制作用比在正常M phi s中更明显。氧氟沙星加LC9018治疗活性的协同作用部分被认为是由宿主M phi s介导的，也就是说，LC9018处理对宿主M phi s的功能刺激导致了两种药物的协同效应。
