Saito H, Tasaka H
J Bacteriol. 1969 Sep;99(3):851-5. doi: 10.1128/jb.99.3.851-855.1969.
The pathogenicity for mice of 12 strains of Mycobacterium abscessus was compared with that for 8 strains of M. fortuitum. Both species caused lesions in kidneys and produced "spinning disease" resulting from inner ear infections. No major differences in pathogenicity of these two species were demonstrated. Strain to strain variation was marked, especially with M. abscessus. For example, 1.6 x 10(6) organisms of strain 11188 of M. abscessus produced death in four of five animals within 42 days, whereas strain 380 of M. abscessus failed to produce any deaths within 42 days. In the case of M. fortuitum, the greatest mortality observed was one of five animals, yet the incidence of spinning disease and kidney disease occurred earlier postinfection than in mice infected with M. abscessus. Histologically, abscess formation by a strain of M. abscessus was greater than by a strain of M. fortuitum, but this difference cannot be interpreted as a species difference.
对12株脓肿分枝杆菌和8株偶然分枝杆菌对小鼠的致病性进行了比较。这两个菌种均可引起肾脏病变，并导致内耳感染引发的“旋转病”。未显示出这两个菌种在致病性上有重大差异。菌株间的差异很显著，尤其是脓肿分枝杆菌。例如，5只动物中有4只在42天内死于接种1.6×10⁶个脓肿分枝杆菌11188菌株的菌体，而脓肿分枝杆菌380菌株在42天内未导致任何死亡。对于偶然分枝杆菌，观察到的最高死亡率为5只动物中有1只死亡，然而，与感染脓肿分枝杆菌的小鼠相比，旋转病和肾病的发病率在感染后出现得更早。组织学上，一株脓肿分枝杆菌形成的脓肿比一株偶然分枝杆菌形成的脓肿更大，但这种差异不能解释为菌种差异。
