Sholapurkar S L, Mahajan R C, Gupta A N, Wangoo A
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Asia Oceania J Obstet Gynaecol. 1990 Mar;16(1):27-32. doi: 10.1111/j.1447-0756.1990.tb00211.x.
A study of lymphocyte subpopulation and leucocyte migration inhibition index (LMI) in 78 pregnant and 22 nonpregnant women with malarial infection (P. vivax 60% and P. falciparum 40%) was done in a hospital in Northern India. Eighty pregnant and 20 nonpregnant women without any infection were also included in the study as controls. T-cell percentage in controls decreased to its lowest in first trimester and gradually rose to nonpregnant levels by the end of puerperium. With malarial infection, there was further drop in T-cell percentage, more so in third trimester. LMI in controls corresponded with T-cell percentage and was depressed in pregnant patients. Enhancement in LMI with malarial infection was depressed in pregnant patients maximally in the third trimester. Parity did not have any influence on these cellular immune parameters. Thus, cellular immunity status in malarial patients was found to be depressed during pregnancy especially in the third trimester.
在印度北部一家医院，对78名感染疟疾（间日疟占60%，恶性疟占40%）的孕妇和22名感染疟疾的非孕妇进行了淋巴细胞亚群和白细胞迁移抑制指数（LMI）研究。另外80名未感染的孕妇和20名未感染的非孕妇也被纳入研究作为对照。对照组中T细胞百分比在孕早期降至最低，产后期末逐渐升至非孕期水平。感染疟疾后，T细胞百分比进一步下降，孕晚期下降更明显。对照组的LMI与T细胞百分比相对应，且在孕妇中降低。感染疟疾后LMI的增强在孕妇中受到抑制，孕晚期抑制作用最大。产次对这些细胞免疫参数没有任何影响。因此，发现疟疾患者的细胞免疫状态在孕期尤其是孕晚期受到抑制。
