Centro de Estudos de Doenças Crónicas (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Campo Mártires da Pátria, 130, 1169-056 Lisboa, Portugal.
Nat Rev Mol Cell Biol. 2013 Apr;14(4):249-62. doi: 10.1038/nrm3541. Epub 2013 Feb 27.
Wound healing is an essential biological process that comprises sequential steps aimed at restoring the architecture and function of damaged cells and tissues. This process begins with conserved damage signals, such as Ca(2+), hydrogen peroxide (H2O2) and ATP, that diffuse through epithelial tissues and initiate immediate gene transcription-independent cellular effects, including cell shape changes, the formation of functional actomyosin structures and the recruitment of immune cells. These events integrate the ensuing transcription of specific wound response genes that further advance the wound healing response. The immediate importance of transcription-independent damage signals illustrates that healing a wound begins as soon as damage occurs.
伤口愈合是一个基本的生物学过程，包括一系列旨在恢复受损细胞和组织的结构和功能的步骤。这个过程始于保守的损伤信号，如 Ca(2+)、过氧化氢 (H2O2) 和 ATP，它们通过上皮组织扩散，引发即时的基因转录非依赖性的细胞效应，包括细胞形状的变化、功能性肌动球蛋白结构的形成和免疫细胞的募集。这些事件整合了随后特定的伤口反应基因的转录，进一步促进了伤口愈合反应。非转录依赖性损伤信号的即时重要性表明，一旦发生损伤，伤口愈合就开始了。
