Cao Xinyue, Wu Xiangyi, Zhang Yuanyuan, Qian Xiaoyun, Sun Weijian, Zhao Yuanjin
Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, 325035, China.
Bioact Mater. 2024 Sep 11;42:449-477. doi: 10.1016/j.bioactmat.2024.09.001. eCollection 2024 Dec.
Complete wound healing without scar formation has attracted increasing attention, prompting the development of various strategies to address this challenge. In clinical settings, there is a growing preference for emerging biomedical technologies that effectively manage fibrosis following skin injury, as they provide high efficacy, cost-effectiveness, and minimal side effects compared to invasive and costly surgical techniques. This review gives an overview of the latest developments in advanced biomedical technologies for scarless wound management. We first introduce the wound healing process and key mechanisms involved in scar formation. Subsequently, we explore common strategies for wound treatment, including their fabrication methods, superior performance and the latest research developments in this field. We then shift our focus to emerging biomedical technologies for scarless wound healing, detailing the mechanism of action, unique properties, and advanced practical applications of various biomedical technology-based therapies, such as cell therapy, drug therapy, biomaterial therapy, and synergistic therapy. Finally, we critically assess the shortcomings and potential applications of these biomedical technologies and therapeutic methods in the realm of scar treatment.
实现无瘢痕形成的完全伤口愈合已引起越来越多的关注，促使人们开发各种策略来应对这一挑战。在临床环境中，人们越来越倾向于采用新兴的生物医学技术来有效管理皮肤损伤后的纤维化，因为与侵入性且昂贵的手术技术相比，这些技术具有高效、成本效益高和副作用小的特点。本综述概述了用于无瘢痕伤口管理的先进生物医学技术的最新进展。我们首先介绍伤口愈合过程以及瘢痕形成所涉及的关键机制。随后，我们探讨伤口治疗的常见策略，包括其制造方法、卓越性能以及该领域的最新研究进展。然后，我们将重点转向用于无瘢痕伤口愈合的新兴生物医学技术，详细阐述各种基于生物医学技术的疗法的作用机制、独特特性和先进实际应用，如细胞疗法、药物疗法、生物材料疗法和协同疗法。最后，我们批判性地评估这些生物医学技术和治疗方法在瘢痕治疗领域的缺点和潜在应用。
