大振荡场中多态酶的动力学
Kinetics of a multistate enzyme in a large oscillating field.
作者信息
Robertson B, Astumian R D
机构信息
Chemical Process Metrology Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
出版信息
Biophys J. 1990 Apr;57(4):689-96. doi: 10.1016/S0006-3495(90)82590-X.
Abstract
A simple, general, and efficient method for calculating the response of a set of coupled first-order (or pseudo-first-order) chemical reactions to an arbitrarily large periodic field is described. The method is applied to a four-state membrane transport enzyme that is electroconformationally coupled to an ac field, i.e., the enzyme has electric charges that move concomitantly with a conformational transition. The calculation is done both for enzymes in a planar membrane and for enzymes in the spherical membrane of a cell or vesicle in suspension.
摘要
描述了一种简单、通用且高效的方法，用于计算一组耦合的一级（或准一级）化学反应对任意大的周期性场的响应。该方法应用于一种与交流场发生电构象耦合的四态膜转运酶，即该酶具有随构象转变而伴随移动的电荷。分别对平面膜中的酶以及悬浮细胞或囊泡的球形膜中的酶进行了计算。
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