Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA.
Expert Rev Gastroenterol Hepatol. 2013 Mar;7(3):281-8. doi: 10.1586/egh.13.6.
This review summarizes literature regarding the role of antimicrobials for induction and maintenance of Crohn's disease (CD) remission. PubMed was searched (1966 to October 2012) for controlled trials involving adults and written in English. Five of the 13 identified studies showed benefit with the use of ciprofloxacin, metronidazole and rifaximin for induction of remission. Eight studies showed no benefit using ciprofloxacin, metronidazole, combination of metronidazole and ciprofloxacin or clarithromycin and rifaximin. Four of the five studies showed benefit based on colonic location. Perianal CD with draining fistulas responded in one of two studies. Two studies in postileocolonic resection demonstrated benefit of metronidazole or ornidazole in reducing CD recurrence. Antimicrobials, especially metronidazole, are promising for inducing remission in patients with colonic CD and preventing recurrence in postileocolonic resection.
这篇综述总结了关于抗生素在诱导和维持克罗恩病（CD）缓解中的作用的文献。检索了 PubMed（1966 年至 2012 年 10 月）中涉及成人的对照试验，并以英文发表。在确定的 13 项研究中有 5 项显示使用环丙沙星、甲硝唑和利福昔明诱导缓解有获益。8 项研究显示使用环丙沙星、甲硝唑、甲硝唑和环丙沙星联合用药或克拉霉素和利福昔明没有获益。其中 5 项研究中的 4 项显示结肠部位获益。肛周 CD 伴引流瘘管在两项研究中的一项中显示获益。在回结肠切除术后的两项研究中，甲硝唑或奥硝唑在降低 CD 复发方面显示获益。抗生素，尤其是甲硝唑，在诱导结肠 CD 缓解和预防回结肠切除术后复发方面有前景。
