Elawabdeh Nancy, Cone Brent M, Abramowsky Carlos R, Wrubel David M, Grossniklaus Hans, Walrath Joseph, Bashir Maaman Z, Shehata Bahig M
Children's Healthcare of Atlanta, Pathology Laboratory, Atlanta, Georgia 30322, USA.
Fetal Pediatr Pathol. 2013 Jun;32(3):184-91. doi: 10.3109/15513815.2012.701265. Epub 2013 Feb 27.
Epstein-Barr virus (EBV) may present few or no symptoms in immunocompetent individuals; however, in immunocompromised patients as in the case of AIDS and post-transplant patients, the virus occasionally stimulates neoplastic transformations. Epstein-Barr virus may play a role in the development of smooth muscle tumors (SMT). In the case of Epstein-Barr associated smooth muscle tumors (EBV+SMT), the virus is thought to be the leading factor to the tumorigenic pathway. We report two pediatric patients (6 and 13 years old) who underwent liver transplantation and developed EBV+SMT in the colon and orbit. These two cases represent rare locations for this kind of lesion.
爱泼斯坦-巴尔病毒（EBV）在免疫功能正常的个体中可能几乎不出现症状或没有症状；然而，在免疫功能低下的患者中，如艾滋病患者和移植后患者，该病毒偶尔会引发肿瘤转化。爱泼斯坦-巴尔病毒可能在平滑肌瘤（SMT）的发生发展中起作用。在爱泼斯坦-巴尔病毒相关平滑肌瘤（EBV+SMT）的病例中，该病毒被认为是致瘤途径的主要因素。我们报告了两名接受肝移植的儿科患者（分别为6岁和13岁），他们在结肠和眼眶出现了EBV+SMT。这两例代表了此类病变罕见的发病部位。
