Fernandes Queenie, Gupta Ishita, Vranic Semir, Al Moustafa Ala-Eddin
College of Medicine, QU Health, Qatar University, Doha 2713, Qatar.
Biomedical Research Centre, Qatar University, Doha 2713, Qatar.
Pathogens. 2020 Apr 20;9(4):300. doi: 10.3390/pathogens9040300.
Human papillomaviruses (HPVs) and the Epstein-Barr virus (EBV) are the most common oncoviruses, contributing to approximately 10%-15% of all malignancies. Oncoproteins of high-risk HPVs (E5 and E6/E7), as well as EBV (LMP1, LMP2A and EBNA1), play a principal role in the onset and progression of several human carcinomas, including head and neck, cervical and colorectal. Oncoproteins of high-risk HPVs and EBV can cooperate to initiate and/or enhance epithelial-mesenchymal transition (EMT) events, which represents one of the hallmarks of cancer progression and metastasis. Although the role of these oncoviruses in several cancers is well established, their role in the pathogenesis of colorectal cancer is still nascent. This review presents an overview of the most recent advances related to the presence and role of high-risk HPVs and EBV in colorectal cancer, with an emphasis on their cooperation in colorectal carcinogenesis.
人乳头瘤病毒（HPVs）和爱泼斯坦-巴尔病毒（EBV）是最常见的致癌病毒，约占所有恶性肿瘤的10%-15%。高危型HPVs的癌蛋白（E5和E6/E7）以及EBV的癌蛋白（LMP1、LMP2A和EBNA1）在包括头颈癌、宫颈癌和结直肠癌在内的多种人类癌症的发生和发展中起主要作用。高危型HPVs和EBV的癌蛋白可以协同启动和/或增强上皮-间质转化（EMT）过程，这是癌症进展和转移的标志之一。尽管这些致癌病毒在几种癌症中的作用已得到充分证实，但其在结直肠癌发病机制中的作用仍处于初期阶段。本综述概述了高危型HPVs和EBV在结直肠癌中的存在情况及作用的最新进展，重点关注它们在结直肠癌发生过程中的协同作用。
