Weidauer L A, Binkley T L, Berry R, Specker B L
Ethel Austin Martin Program in Human Nutrition, South Dakota State University.
J Musculoskelet Neuronal Interact. 2013 Mar;13(1):89-96.
The purpose of this study was to determine variability in cortical volumetric bone density (vBMD) from a single slice tibia image over a range of vBMD readings and ages.
Males and females (N=80; aged 6-80) were randomly selected from a previous study. Cortical vBMD at the anterior, posterior, medial, and lateral regions as well as the endocortical, mid-cortical, and pericortical regions of the cortical shell were determined using pQCT.
Mean anterior ROI cortical vBMD (1111±11 mg/cm(3)) was lower than the posterior and lateral ROIs (1169±7 mg/cm(3) and 1151±9 mg/cm(3), respectively), (p<0.05). Individuals with lower overall cortical vBMD and younger individuals had greater vBMD variability within the shell (r=0.37, p=0.004). Difference between anterior and posterior regions was inversely associated with cortical vBMD and jump power (r=0.46, p=0.001). Endocortical vBMD (1080±6 mg/cm) was lower than the mid-cortical and pericortical regions (1152±5 mg/cm(3) and 1147±5 mg/cm, respectively).
Variability in cortical vBMD was higher among young individuals and those with lower overall cortical vBMD, while lowest in older individuals and men. The anterior ROI had lower mean cortical vBMD than posterior or lateral regions, and endocortical vBMD was lower than the mid- and pericortical regions.
本研究旨在确定在一系列骨密度读数和年龄范围内，单切片胫骨图像中皮质骨体积骨密度（vBMD）的变异性。
从先前的一项研究中随机选取男性和女性（N = 80；年龄6 - 80岁）。使用外周定量计算机断层扫描（pQCT）测定皮质骨壳的前部、后部、内侧和外侧区域以及皮质内、皮质中、皮质周区域的皮质vBMD。
前部感兴趣区（ROI）的平均皮质vBMD（1111±11mg/cm³）低于后部和外侧ROI（分别为1169±7mg/cm³和1151±9mg/cm³），（p<0.05）。总体皮质vBMD较低的个体和较年轻的个体在骨壳内的vBMD变异性更大（r = 0.37，p = 0.004）。前部和后部区域之间的差异与皮质vBMD和跳跃功率呈负相关（r = 0.46，p = 0.001）。皮质内vBMD（1080±6mg/cm）低于皮质中和皮质周区域（分别为1152±5mg/cm³和1147±5mg/cm）。
年轻个体和总体皮质vBMD较低的个体中皮质vBMD的变异性较高，而在老年个体和男性中最低。前部ROI的平均皮质vBMD低于后部或外侧区域，皮质内vBMD低于皮质中和皮质周区域。
