一种用于区域皮质骨矿物质密度分析的开源方法。

An open source approach for regional cortical bone mineral density analysis.

作者信息

Rantalainen T, Nikander R, Heinonen A, Daly R M, Sievanen H

机构信息

Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, Melbourne, VIC 3125, Australia.

出版信息

J Musculoskelet Neuronal Interact. 2011 Sep;11(3):243-8.

PMID:21885899

Abstract

OBJECTIVE

Cortical porosity, particularly at the endocortical region, is recognised to play a central role in the pathogenesis of bone fragility. Therefore, the purpose of this study was to: 1) demonstrate how cortical volumetric BMD (vBMD) distribution can be analysed from (p)QCT images and 2) highlight the clinical significance of assessing regional density distribution of cortical bone.

METHODS

We used pQCT to compare mid-tibial cortical volumetric BMD distribution of 20 young (age 24(SD2) years, mass 77(11) kg, height 178(6) cm) and 25 elderly (72(4) years, 75(9) kg, 172(5) cm) men. Radial and polar cortical vBMD distributions were analysed using a custom built open source analysis tool which allowed the cortex to be divided into three concentric cortical divisions and in 36 cortical sectors originating from the centroid of the bone.

RESULTS

Mean vBMD did not differ between the groups (1135(16) vs. 1130(28) mg/cm, P = 0.696). In contrast, there was a significant age-group by radial division interaction for radial cortical vBMD (P<0.001).

CONCLUSIONS

The proposed analysis method for analysing cortical bone density distribution of pQCT images was effective for detecting regional differences in cortical density between young and elderly men, which would have been missed by just looking at mean vBMD values.

摘要

目的

皮质骨孔隙率，尤其是在内皮质区域，被认为在骨脆性发病机制中起核心作用。因此，本研究的目的是：1）展示如何从（p）QCT图像分析皮质骨体积骨密度（vBMD）分布，以及2）强调评估皮质骨区域密度分布的临床意义。

方法

我们使用pQCT比较了20名年轻男性（年龄24（标准差2）岁，体重77（11）千克，身高178（6）厘米）和25名老年男性（72（4）岁，75（9）千克，172（5）厘米）胫骨中段皮质骨体积骨密度分布。使用定制的开源分析工具分析径向和极向皮质骨vBMD分布，该工具可将皮质骨分为三个同心皮质分区，并在源自骨中心的36个皮质扇区中进行分析。