Lacinová Z, Hájek Z, Srp B, Fialová L, Kulovaný E, Melková J
I. gynek.-porod. klinika FVL KU, Praha.
Cesk Gynekol. 1990 Mar;55(2):81-7.
The authors investigate the importance of examination of total urinary oestrogens (ET), oestriol (E3) trophoblast-specific beta-1-globulin (SP1) and alpha-1-antrypsin (A1AT) in the blood in a group of 56 pregnant women with suspection of a hypotrophic foetus. They made 192 analyses of ET, 144 E3; 153 SP1; 124 A1AT. With regard to the state of the neonate after delivery they divided the group into sub-groups with a eutrophic neonate and the group with a hypotrophic neonate, and the group with a hypotrophic neonate. They proved by statistical methods a different incidence of pathological values of ET, E3 and SP1 in the two sub-groups. A1AT rises in both sub-groups with advancing pregnancy. The incidence of pathological values was not significant. Assessment of ET is indispensible in any obstetric department; repeated examination is necessary, as one result does not provide adequate information on the function of the placenta and state of the foetus. To confirm the diagnosis, several biochemical parameters should be assessed.
作者对56名疑似胎儿发育迟缓的孕妇进行了研究，检测了她们尿液中总雌激素（ET）、雌三醇（E3）、滋养层特异性β-1球蛋白（SP1）以及血液中α-1抗胰蛋白酶（A1AT）的重要性。他们对ET进行了192次检测，E3进行了144次检测，SP1进行了153次检测，A1AT进行了124次检测。根据分娩后新生儿的状况，他们将该组孕妇分为新生儿发育正常的亚组和新生儿发育迟缓的亚组。他们通过统计学方法证明，ET、E3和SP1的病理值在这两个亚组中的发生率不同。随着孕周增加，两个亚组中的A1AT水平均升高。病理值的发生率无显著差异。在任何产科部门，ET的评估都是必不可少的；由于单次检测结果无法充分提供胎盘功能和胎儿状况的信息，因此有必要进行重复检测。为了确诊，应评估多个生化参数。
