[Detection of pregnancy-specific beta 1-glycoproteins (SP1) and pregnancy-associated plasma protein A (PAPP-A) in maternal serum. Diagnostic significance in intrauterine fetal retardation].

The problem was to prove the value of SP1 (pregnancy specific beta 1-glycoprotein) and PAPP-A (pregnancy-associated plasmaprotein A) estimations in maternal serum samples for diagnosis of intrauterine growth retardation (IUGR). After delivery the pediatrician confirmed the diagnose of IUGR by means of clinical assessment. SP1 was estimated in 25 serum samples from 8 patients with IUGR and in 36 samples from healthy women by means of single radial immunodiffusion (24h-RID). Low SP1-values were found in serum samples from 4 patients with IUGR. There was a significant correlation (p less than 0,01) between SP1 concentrations and pregnancy weeks only in the control group. The regression line of the IUGR group was not different from 0 significantly. The estimations of PAPP-A were performed in 17 serum samples from 6 patients with IUGR. 24 serum samples from 12 healthy pregnant women were applied to control group. There was no difference between the 2 groups. PAPP-A is not suitable for diagnosis of IUGR.