Xu Jian-bo, He Yu-long, Wu Hui, Zhang Xin-hua, Ma Jin-ping, Peng Jian-jun, Chen Chuang-qi, Cai Shi-rong, Zhan Wen-hua
Department of Gastrointestinal and Pancteatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Feb;16(2):160-2.
To summarize the clinicopathological characteristics and analyze the prognostic factors of young patients with gastric cancer.
A total of 99 patients with the age less than or equal to 40 were admitted in The First Affiliated Hospital of Sun Yat-sen University from August 2001 to December 2009. Their clinicopathological and follow-up data were compared with middle-aged and elderly patients with the age more than 40.
There were statistically significant differences in gender, tumor location, Borrmann type, histological type, differentiated histology, depth of invasion, peritoneal metastasis between young patients and elder ones. The 5-year survival rates of young and elder patients were 49.1% and 44.4% respectively, and the difference was not statistically significant (P>0.05). Univariate and multivariate analyses showed that TNM stage (P=0.014) and surgical methods (P=0.012) were independent predictive factors of survival for young patients. For the young patients, the 5-year survival rate was 56.7% after curative resection, 11.1% after palliative resection. Those who underwent palliative surgery or biopsy alone died within 1 year after surgery. The difference between difference surgical procedures in survival were statistically significant (P<0.05).
As compared to elder patients, young patients with gastric cancer have special clinicopathological features. However, no significant difference of survival rate is found between the young and the elder patients. TNM stage and surgical methods are independent prognostic factors of young patients with gastric cancer. Radical resection appears to confer the only chance of prolonged survival.
总结青年胃癌患者的临床病理特征并分析其预后因素。
2001年8月至2009年12月中山大学附属第一医院共收治99例年龄小于或等于40岁的患者，将其临床病理及随访资料与年龄大于40岁的中老年患者进行比较。
青年患者与老年患者在性别、肿瘤部位、Borrmann分型、组织学类型、分化程度、浸润深度、腹膜转移方面存在统计学差异。青年患者和老年患者的5年生存率分别为49.1%和44.4%，差异无统计学意义（P>0.05）。单因素和多因素分析显示，TNM分期（P=0.014）和手术方式（P=0.012）是青年患者生存的独立预测因素。对于青年患者，根治性切除术后5年生存率为56.7%，姑息性切除术后为11.1%。仅接受姑息性手术或活检的患者术后1年内死亡。不同手术方式的生存率差异有统计学意义（P<0.05）。
与老年患者相比，青年胃癌患者具有特殊的临床病理特征。然而，青年患者与老年患者的生存率无显著差异。TNM分期和手术方式是青年胃癌患者的独立预后因素。根治性切除似乎是延长生存的唯一机会。
